Conformation, hydrogen bonding and aggregate formation of guanosine 5′-monophosphate and guanosine in dimethylsulfoxide
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چکیده
منابع مشابه
Nonenzymatic formation of guanosine 3':5'-monophosphate from guanosine triphosphate.
We observed the nonenzymatic formation of guanosine 3’:5’-monophosphate (cyclic GMP) from GTP. The reaction was dependent upon heat and was accelerated by divalent cations and creatine phosphate. The formation of cyclic GMP was greater with increased incubation time, temperature, GTP concentration, and pH. All of the divalent cations tested (Mg2+, Mnz+, Ca2+, Ba2+, and Znzf) increased cyclic GM...
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Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in the pathophysiology of the heart and its modulation by drugs such as phosphodiesterase (PDE)-5 inhibitors and guanylate cyclase activators may represent a promising therapeutic approach for acute myocardial infarction, ca...
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The occurrence of cyclic guanosine 3’,5’-monophosphate (3’,5’-cGMP) as a natural constituent of mammalian tissues was established, and details of a method for its quantitative determination in milligram amounts of liver, kidney, and brain or in microliter samples of urine are presented. In the analytical procedure 3’,5’-cGMP partially purified from tissue extracts by thin layer chromatography o...
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Since we have previously shown a direct inhibitory effect of platelet-activating factor (PAF) on Cl reabsorption in the medullary thick ascending limb of Henle's loop (TAL), the aim of this study was to extend this effect to the whole TAL and to further investigate the signaling pathway involved. In microperfused cortical TALs, PAF significantly decreased Cl reabsorption by 50.3±6.5%. On the on...
متن کاملUrinary excretion of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate in malignancy.
The urinary excretion of cyclic adenosine 3',5'-monophosphate (cAMP), corrected for urinary creatinine, was determined in 177 patients with primary or metastatic tumours and in 149 normal subjects. In 26 patients with malignancy and in 10 control subjects the excretion of cyclic guanosine 3',5'-monophosphate (cGMP) was also evaluated. The urinary cAMP/Cr ratio in human neoplasms of epithelial o...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1994
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/22.23.5128